publications

publications by categories in reversed chronological order.

2025

  1. Recording_design.jpg
    Molecular circuits for genomic recording of cellular events
    Wei Chen, and Junhong Choi
    Trends in Genetics, 2025

2024

  1. chromatin.jpg
    Chromatin context-dependent regulation and epigenetic manipulation of prime editing
    Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy McDiarmid, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, and Jay Shendure
    Cell, 2024
  2. ENGRAM.jpg
    Symbolic recording of signalling and cis-regulatory element activity to DNA
    Wei Chen, Junhong Choi, Xiaoyi Li, Jenny F Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazaki, Chengxiang Qiu, Jean-Benoı̂t Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, and Jay Shendure
    Nature, 2024
  3. recording_review.jpg
    The lives of cells, recorded
    Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, Michael B. Elowitz, James A. Gagnon, Alexander F. Schier, Sophie Seidel, Jay Shendure, Tanja Stadler, and Martin Tran
    Nature Reviews Genetics, 2024

2023

  1. Computational design of sequence-specific DNA-binding proteins
    Cameron J Glasscock, Robert Pecoraro, Ryan McHugh, Lindsey A Doyle, Wei Chen, Olivier Boivin, Beau Lonnquist, Emily Na, Yuliya Politanska, Hugh K Haddox, and  others
    bioRxiv, 2023

2022

  1. prime-del.jpg
    Precise genomic deletions using paired prime editing
    Junhong Choi, Wei Chen, Chase C Suiter, Choli Lee, Florence M Chardon, Wei Yang, Anh Leith, Riza M Daza, Beth Martin, and Jay Shendure
    Nature Biotechnology, 2022
  2. DDT.jpg
    A time-resolved, multi-symbol molecular recorder via sequential genome editing
    Junhong Choi, Wei Chen, Anna Minkina, Florence M. Chardon, Chase C. Suiter, Samuel G. Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M. Daza, and Jay Shendure
    Nature, 2022

2019

  1. Modeling_layout.jpg
    Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
    Wei Chen, Aaron McKenna, Jacob Schreiber, Maximilian Haeussler, Yi Yin, Vikram Agarwal, William Stafford Noble, and Jay Shendure
    Nucleic acids research, 2019

2018

  1. Identifying novel enhancer elements with CRISPR-based screens
    Jason C Klein, Wei Chen, Molly Gasperini, and Jay Shendure
    ACS chemical biology, 2018
  2. Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
    Alexander B. Rosenberg, Charles M. Roco, Richard A. Muscat, A. Kuchina, Paul J. Sample, Zizhen Yao, Lucas T. Graybuck, David J. Peeler, S. Mukherjee, Wei Chen, S. Pun, D. Sellers, Bosiljka Tasic, and Georg Seelig
    Science, 2018