Chenomics

programmable gene expression · molecular recording · protein design

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I am Wei Chen, a genomicist developing new technologies to understand the genome through a biophysical lens.

I am currently a Damon Runyon Postdoc Fellow at Institute of Protein Design, working with David Baker. Previously, I did my Ph.D under the supervision of Jay Shendure.

My research focuses on developing high-throughput quantitative technologies to understand human genome and protein functions. Currently, I am designing de novo proteins with novel functions to manipulate cell behaviors.

news

Jul 23, 2025 Hello world, this website is online now.

selected publications

2026

  1. Wei Chen, R. Jiao, Brian Coventry, X. Qu, M. S. Bauer, L. Tran, Tabitha Tcheau, Kejia Wu, Z. Song, N. Roullier, Xiaoyi Li, Cameron Glasscock, Isaac B Hilton, and David Baker
    bioRxiv, 2026

2025

  1. Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, Michael B. Elowitz, James A. Gagnon, Alexander F. Schier, Sophie Seidel, Jay Shendure, Tanja Stadler, and Martin Tran
    Nature Reviews Genetics, 2025

2024

  1. Wei Chen, Junhong Choi, Xiaoyi Li, Jenny F Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazaki, Chengxiang Qiu, Jean-Benoı̂t Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, and Jay Shendure
    Nature, 2024

2022

  1. Junhong Choi, Wei Chen, Chase C Suiter, Choli Lee, Florence M Chardon, Wei Yang, Anh Leith, Riza M Daza, Beth Martin, and Jay Shendure
    Nature Biotechnology, 2022
  2. Junhong Choi, Wei Chen, Anna Minkina, Florence M. Chardon, Chase C. Suiter, Samuel G. Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M. Daza, and Jay Shendure
    Nature, 2022

2019

  1. NAR
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    Wei Chen, Aaron McKenna, Jacob Schreiber, Maximilian Haeussler, Yi Yin, Vikram Agarwal, William Stafford Noble, and Jay Shendure
    Nucleic acids research, 2019