Chenomics

I am Wei Chen, a genomicist developing new technologies to understand the genome through a biophysical lens.

I am currently a Damon Runyon Postdoc Fellow at Institute of Protein Design, working with David Baker. Previously, I did my Ph.D under the supervision of Jay Shendure.

My research focuses on developing high-throughput quantitative technologies to understand human genome and protein functions. Currently, I am designing de novo proteins with novel functions to manipulate cell behaviors.

news

Jul 23, 2025	Hello world, this website is oneline now.

selected publications

2025

The lives of cells, recorded

Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, Michael B. Elowitz, James A. Gagnon, Alexander F. Schier, Sophie Seidel, Jay Shendure, Tanja Stadler, and Martin Tran

Nature Reviews Genetics, 2025

2024

Symbolic recording of signalling and cis-regulatory element activity to DNA

Wei Chen, Junhong Choi, Xiaoyi Li, Jenny F Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazaki, Chengxiang Qiu, Jean-Benoı̂t Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, and Jay Shendure

Nature, 2024

2022

Precise genomic deletions using paired prime editing

Junhong Choi, Wei Chen, Chase C Suiter, Choli Lee, Florence M Chardon, Wei Yang, Anh Leith, Riza M Daza, Beth Martin, and Jay Shendure

Nature Biotechnology, 2022
A time-resolved, multi-symbol molecular recorder via sequential genome editing

Junhong Choi, Wei Chen, Anna Minkina, Florence M. Chardon, Chase C. Suiter, Samuel G. Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M. Daza, and Jay Shendure

Nature, 2022

2019

Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair

Wei Chen, Aaron McKenna, Jacob Schreiber, Maximilian Haeussler, Yi Yin, Vikram Agarwal, William Stafford Noble, and Jay Shendure

Nucleic acids research, 2019